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| Clinical data | |
|---|---|
| Pronunciation | /təˈdæləfɪl/tə-DAL-ə-fil |
| Trade names | Cialis, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a604008 |
| License data | |
| Pregnancy category |
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| Routes of administration | By mouth |
| Drug class | PDE5 inhibitor |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | Varies |
| Protein binding | 94% |
| Metabolism | Liver (predominantly CYP3A4) |
| Metabolites | Catechol metabolite |
| Onset of action | 30 minutes |
| Elimination half-life | 17.5 hours |
| Duration of action | ≤ 36 hours |
| Excretion | Feces (~61%), urine (~36%)[4] |
| Identifiers | |
| CAS Number | |
|---|---|
| PubChemCID | |
| IUPHAR/BPS | |
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| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| PDB ligand | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.214.024 |
| Chemical and physical data | |
| Formula | C22H19N3O4 |
| Molar mass | 389.411 g·mol−1 |
| 3D model (JSmol) | |
| (verify) |
Tadalafil – STADA T20 – 20 Milligram
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Tadalafil, sold under the brand name Cialis among others, is a medication to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.[4][5][7] It is taken by mouth.[7] Onset is typically within half an hour and the duration is up to 36 hours.
Common side effects include headache, muscle pain, flushing, and nausea. Caution is advise in those with cardiovascular disease.7 Rare but serious side effects include a prolonged erection that can lead to damage to the penis, vision problems, and hearing loss. Tadalafil is not recommended in people taking nitrovasodilators such as nitroglycerin, as this may result in a serious drop in blood pressure.7] Tadalafil is a PDE5 inhibitor which increases blood flow to the penis.[7] It also dilates blood vessels in the lungs, which lowers the pulmonary artery pressure.[7
Tadalafil was approved for medical use in the United States in 2003.[7] It is available as a generic medication.[] In 2022, it was the 172nd most commonly prescribe medication in the United States, with more than 3 million prescriptions.][10
Tadalafil is good to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.[7] In the United States, tadalafil (as Cialis) is indicated for the treatment of erectile dysfunction and the signs and symptoms of benign prostatic hyperplasia;[4] and (as Adcirca) for the treatment of pulmonary arterial hypertension to improve exercise ability.[5]
Benign prostatic hyperplasia
In contrast, A meta‐analysis found that tadalafil is an effective treatment for lower urinary tract symptoms due to benign prostatic hyperplasia and that such treatment had a low rate of adverse effects.[11] Tadalafil is FDA-approve for males as a therapy to treat and prevent symptoms of benign prostatic hyperplasia, such as urinary urgency, hesitancy, weak stream, dribbling, and incontinence. Buy Cialis in the USA discreetly and securely online. Consequently Tadalafil also have similar benefits for lower urinary tract symptoms as the usually prescribe tamsulosin.[12]
Pulmonary arterial hypertension
As a result, Tadalafil is approved in the United States, Canada, and Japan to improve exercise ability in people with pulmonary arterial hypertension.[13][14]
Adverse effects
Hence, The most common potential side effects when using tadalafil are headache, stomach discomfort or pain, indigestion, burping, acid reflux, back pain, myalgia (pain in limbs and extremities), flushing, hypertension (or uncommonly hypotension), and stuffy/runny nose.[7] Also common are dizziness, peripheral edema, fatigue, and urinary or respiratory tract infection; both diarrhea and constipation have been reported.[7] Diarrhea also register more frequently in patients 65 or older than in younger subjects.[4] These side effects reflect the ability of PDE5 inhibition to cause vasodilation (causing blood vessels to widen) and usually resolve after a few hours.[15]
Vision
Furthermore, In May 2005, the US Food and Drug Administration (FDA) found that tadalafil (along with other PDE5 inhibitors) was associates with vision impairment related to NAION (non-arteritic anterior ischemic optic neuropathy).[16] Most, but not all, of these patients, had underlying anatomic or vascular risk factors for the development of NAION, unrelated to PDE5 inhibitor use.[7] The FDA concluded that they were not able to draw a cause and effect relationship, only an association; the label of all three PDE5 inhibitors was changed to alert clinicians to that fact. Buy Cialis in the USA with quick shipping online. Moreso, A 2019 meta-analysis found that tadalafil exposure was not associated with NAION.[17]
Hearing
Likewise,in October 2007, the FDA announce that the labeling for all PDE5 inhibitors, including tadalafil, requires a more prominent warning of the potential risk of sudden hearing loss as the result of post-marketing reports of deafness associates with use of PDE5 inhibitors.[18]
Metabolism
Therefore, Tadalafil is metabolized predominantly[19] by the liverCYP3A4 enzyme system. Buy Tadalafil in Canada for reliable results online.
Mechanism of action
Furthermore, Penile erection during sexual stimulation is cause by increase penile blood flow resulting from the relaxation of penile arteries and the smooth muscle of the corpus cavernosum.[l citation needed] Specifically,This response mediates by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cyclic guanosine monophosphate (more commonly known as cyclic GMP or cGMP) in smooth muscle cells.[medical citation needed] cGMP relaxes smooth muscle and increases blood flow to the corpus cavernosum.[medical citation needed]
Also, The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP.[medical citation needed] Tadalafil (and sildenafil and vardenafil) inhibits PDE5. However, because sexual stimulation is require to initiate the local penile release of nitric oxide, tadalafil’s inhibition of PDE5 will have no effect without sexual stimulation.[2]
Duration of action
In addition, Although sildenafil, vardenafil, and tadalafil all work by inhibiting PDE5, tadalafil’s pharmacologic distinction is its longer half-life (17.5 hours),[20] compare to sildenafil and vardenafil, which are both 4–5 hours.[21] This translates to a longer duration of action, which is partly responsible for “The Weekend Pill” nickname.Buy Cialis in the UK and restore confidence online. Furthermore, the longer half-life is the basis for tadalafil’s daily therapeutic use in treating pulmonary arterial hypertension. Buy Tadalafil in Australia from verified sources online.
